Ana Isabel Roque is currently undertaking her PhD in Biology at NOVA School of Science and Technology and Center for Innovative Care and Health Technology, Polytechnic of Leiria. Her research is focused on unraveling celiac disease’s autoimmunity mechanisms possibly mediated by bacteria. As a Visiting Student Researcher at Professor Fasano’s laboratory at the Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Harvard Medical School, and supported by the Fulbright Program, she plans to employ an intestinal organoid-bacteria co-culture model to infer if commensal bacteria can disrupt and translocate the intestinal epithelial barrier and contribute to the autoimmune response observed in celiac patients. She hopes to provide new insights into specific host-bacteria interactions and their influence on host responses to environmental disease triggers that may enable the discovery of pathogenic targets and development of new therapeutic or preventive approaches.

Harvard Medical School

Grant duration: 8 months